【摘要】 目的：探讨克罗卡林对离体大鼠心肌梗死范围的影响及机制。方法：用离体大鼠心脏双冠状动脉分别灌流模型，将左冠状动脉灌流量减到原灌流量的５％，进行不完全缺血６０分钟，再进行２小时再灌注。结果：１μｍｏｌ／Ｌ克罗卡林在缺血前及缺血中投予可明显缩小心肌梗死范围，分别从对照组的１９．８％下降到９．６％和８．４％（Ｐ＜０．０５），而再灌注期间用药无效。其作用可被三磷酸腺苷敏感性钾通道阻滞剂格列本脲所阻滞，心肌梗死范围从克罗卡林组的７．３％增加到克罗卡林＋格列本脲组的１６．７％（Ｐ＜０．０５）。结论：克罗卡林有缩小大鼠心肌梗死范围的作用，机制是通过激活三磷酸腺苷敏感性钾通道实现的更多还原

【Abstract】 Objective:To study the infuluence and mechanism of cromakalim on myocardial infarct size in isolated rat heart. Methods:Isolated rat heart was subjected to dual coronary perfusion model.The flow of the left coronary bed was reduced to 5% of basal flow for 60 min of ischemia and then reperfused for 2 hours. Results:The 1 μmol/L cromakalim was administered at preischaemic,ischaemic or reperfused period.It was shown that the infarct size was decreased from 19 8% in the control to 9 6% and 8 4% in preischemic and ischemic group,respectively (both p <0 05).No effect was observed in the reperfused group.The effect of cromakalim was completely blocked by glibenclamide and the infarct size was increased from 7 3% in the cromakalim group to 16 7% in the cromakalim plus glibenclamide group ( p <0 05). Conclusion:Cromakalim can limit myocardial infarct size in isolated rat heart,and the effect appeared to be due to the opening of ATP sensitive K + channel.更多还原