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小熊猫接种犬瘟热疫苗后的抗体检

Detection of neutralizing antibodies after Inoculation of Canine distemper vaccine in lesser pandas

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【作者】 陈培富; 陆承平; 徐麟木; 郭爱珍; 郑保纹;

【Author】 Chen Peifu Lu Chengping Xu Linmu Guo Aizhen Zhen Baowen (College of Veterinary Medicine, Nanjing Agriculture University, Nanging, Jiangsu, 210095)

【机构】 南京农业大学动物医学院;

【摘要】 以犬用犬瘟热(CD)弱毒疫苗接种从产地新引入南京市玄武湖动物园的2只小熊猫(A组),在接种后11个月内每月采血1次,用微量中和试验检测其体内抗犬瘟热病毒(CDV)抗体效价。结果显示,小熊猫接种后1个月时抗体效价已达1∶1000左右,2个月时效价最高,达1∶2000左右,而后缓慢下降,至7和11个月时分别约为1∶100和1∶20。同时检测了以前接种过同一疫苗的3只该动物园自己繁育的小熊猫(B组)和福州市动物园内的6只小熊猫(C组)的CDV中和抗体效价,其效价变化类似于A组。这些小熊猫在接种前均确认健康,在试验期间同样的饲养条件下未发生CD,提示犬用CD疫苗可用于小熊猫的CD预防,其产生的有效免疫力至少可持续6个月。

【Abstract】 Two lesser pandas which newly introduced (group A) from their natural habitat into Xuanwu lake zoo in Nanjing were inoculated with attenuated canine distemper (CD) vaccine. Blood samples were collected once a month after inoculation during 11th month, antibody titer by microtitre neutralization test showed that group A was of about 1∶1000 in 1st month, increased to the highest about 1∶2000 in 2nd month, and then declined slowly througth the following months to 1∶100 in 7th month and 1∶20 in 11th month, respectively. Simultaneously, another 3 lesser pandas born in the zoo (group B) and 6 ones in Fuzhou zoo (group C), which were previously vaccinated with the same vaccine, were also detected, their changes of anti CDV antibody titers were similar with group A. These lesser pandas kept in good health before vaccination, No CD occurred in the raising condition during the experiment period. It suggesting that CD vaccine for dog could be applied for lesser panda and provide the efficient immunity of 6 month at least.

  • 【文献出处】 中国兽医科技 ,CHINESE JOURNAL OF VETERINARY SCIENCE AND TECHNOLOGY , 编辑部邮箱 ,1998年12期
  • 【分类号】S858.9
  • 【被引频次】14
  • 【下载频次】104
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