【摘要】 目的：探讨层粘蛋白（ＬＮ）及血管内皮完整性受损在妊高征及妊娠期肝内胆汁淤积症（ＩＣＰ）等并发症发病中的作用和意义。方法：测定４０４例妊娠晚期孕妇血清ＬＮ浓度，比较对照组、妊高征组、ＩＣＰ组、羊水过少组、ＩＵＧＲ组和巨大儿组血清ＬＮ水平的差异。结果：妊高征组和ＩＣＰ组血清ＬＮ水平显著高于对照组，差异有显著性（均Ｐ＜００１）；羊水过少、ＩＵＧＲ及巨大儿组与对照组差异无显著性（均Ｐ＞００５）；轻度、中度和重度妊高征间差异无显著性（均Ｐ＞００５）。结论：血清ＬＮ升高可能与妊高征及ＩＣＰ等并发症的发病过程有关。更多还原

【Abstract】 Objective:To evaluate the role of increased serum laminin(LN)and endothelial injury in the development of pregnancy induced hypertension(PIH)and intrahepatic cholestasis during pregnancy(ICP).Methods:Serum LN was determined in 404 women in late pregnancy who were divided into six groups:PIH,ICP,oligoamnios,intrauterine growth retardation(IUGR),fetal macrosomatia and control.Serum LN concentrations were compared among these groups.Results:Compared with that of contral,serum LN concentrations were significantly increased in both PIH and ICP(P<0.001,for both),but not in oligoamnios,IUGR and fetal macrosomatia(P>0.5,for all).No significant difference was found among patients with mild,moderate and severe PIH(P<0.2 for all).Conclusion:Increased serum laminin may be related to the development of PIH and ICP.更多还原