【摘要】 目的探讨p53蛋白、增殖细胞核抗原（PCNA）在乳腺浸润性导管癌中表达的相关性及和预后的关系。方法应用免疫组织化学ABC法检测乳腺浸润性导管癌组织P53蛋白和PCNA的表达。结果死亡组P53蛋白阳性表达率（32／35）和PCNA指数（PI）（56．5％±26．54％）明显高于存活组的P53蛋白阳性率（31／65）和PI（31．5％±26．88％）。且两者表达与淋巴结转移和临床分期有显著关系。结论p53蛋白表达与PI间有显著的正相关关系，两者综合指标（PI＞50％，P53+）对于估测患者预后有重要意义。更多还原

【Abstract】 To investigate the relationship between p53 and PCNA (proliferating cell nuclear antigen) expression in breast invasive ductal carcinoma and their significance in prognosis. METHODS The expression of p53 andPCNA was detected in breast invasive ductal carcinoma by immunohistochemical ABC method. RESULTS Thepostive rate of p53 expression and PCNA index (PI) were significantly higher in the dead patients than in survivingpatients. p53 positivity and PI were 32/35 and 56. 5 % f 26. 54 respectively in dead cases. 31/65 and 31. 5 % ±26.88 in surviving cases. The expression of p53 and PCNA was markedly correlated with lymph node metastasis andclinical staging. CONCLUSION p53 expression was postitively correlated with PI. These two markers combined(PI>50%, p53+ ) may be used as an important indicator of prognosis in breast carcinoma.更多还原