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β-萘酚黄酮诱导缺血心肌黄酶基因表达的研究
Study on Gene expression of DT diaphorase in ischemic myocardium from rats induced by β naphthoflavone
【摘要】 用β-萘酚黄酮诱导大鼠缺血心肌黄酶基因表达,结果证明:诱导组大鼠心肌黄酶活性升高是对照组的4倍,缺血组的3倍。由于酶的基因表达,阻止了心肌细胞膜的脂质过氧化,使线粒体膜心磷脂水平增加,线粒体呼吸酶—细胞色素氧化酶活性升高,心肌细胞超微结构优于缺血组,保护了缺血心肌细胞。
【Abstract】 This paper described the gene expression of DT-diaphorase in ischemic myocardium from rats induced by β naphthoflavone.The results showed that in induce group,the activity of DT-diaphorase in the cytosol increased several times compared with that of the vehicle control.Because of gene expression of the enzyme,it prevented peroxidation of cell membrane and protected myocardial cells.The cardiolipin level of the mitochondria increased.The ultrastructure of myocardial cells was better than that of ischemic control.
【基金】 辽宁省教委基金
- 【文献出处】 中国地方病学杂志 ,CHINESE JOURANL OF CNDEMIOLOGY , 编辑部邮箱 ,1998年06期
- 【分类号】R364.12
- 【被引频次】5
- 【下载频次】44