【摘要】 通过对子午岭林区克山病重病区某林场职工进行普查，筛选出克山病患者４８例。对无明显心功能障碍的患者进行了补硒和维生素Ｅ干预试验，疗程三个月，治疗前后检测了甲襞微循环、血液流变学及心电图等指标。并与年龄、性别、职业等相似的健康对照组进行了对照。结果提示克山病患者纤维蛋白原、血沉方程Ｋ值、体外血栓长度显著高于健康对照组，表明红细胞聚集性增加，干预后纤维蛋白原有明显下降。补硒和维生素Ｅ对血浆比粘度无明显影响。克山病患者红细胞刚性值，全血比粘度，全血还原粘度降低，提示红细胞变形性增加，补硒和维生素Ｅ后基本恢复正常。表明硒和维生素Ｅ可有效改善克山病患者的血液流变学指标。更多还原

【Abstract】 To study the effects of selenium and vitamin E on the treatment of Keshan disase,a general survey was carried out among workers in a forestry center of Ziwulin forest region and 48 patients with Keshan disease were found.Selenium and vitamin E were given to 32 patients who had no obvious heart dysfunction for three months.Microcirculation of nail fold,rheology indexes and electrocardiogram were detected before and after treatment and compared with those of healthy control group.Results showed that fibrinogen,blood sedimentation equation K value and thrombus length in vitro were significantly higher in Keshan disease patients than those in healthy control and significantly decreased after treatment (P<0.01),while index of rigidity in red blood cells,whole blood specific viscosity and reduced whole blood viscosity were decreased in Keshan disease patients and nearly reached normal after treatment.Both selenium and vitamin E supplementation had no obvious influence on plasma viscosity.These results indicate selenium and vitamin E can effectively improve blood rheology indexes of Keshan disease.更多还原