【摘要】 花椒毒酚（xanthotoxol，XT）是从蛇床子中提取出的一种呋喃香豆素。XT对二甲苯所致小鼠耳壳肿胀、醋酸引起的小鼠腹腔毛细血管通透性增高、大鼠角叉菜胶性足跖肿胀均有明显的抑制作用，对小鼠棉球肉牙肿增生也有明显的抑制作用。结果表明XT对急性和慢性炎症模型均有抗炎作用。此外，XT明显降低大鼠角叉菜胶性足跖炎症组织内PGE含量。更多还原

【Abstract】 Xanthotoxol (XT) is a furan-coumarin isolated from the fruit of cnidium monnieri(L. ) Cusson. XT suppressed the swelling of mouse ear induced by xylene,the increase of peritoneal capillary permeability induced by HAc in mice and edema of rat hind paw induced by carrageenan. XT inhibited the proliferation of granuloma induced by imlpanting cotton pellets in mice. These results indicated that XT diminished acute and chronic inflammation in animal models. Furthermore,XT decreased the contents of prostaglandin E in inflammatory tissue of rat hind paw induced by carrageenan.更多还原