【摘要】 目的和方法：观察７５ｍＧｙＸ射线全身照射昆明系雄性小鼠后２４ｈ，其血清及胸腺和脾细胞外液对免疫功能的影响。结果：小鼠经７５ｍＧｙ照射后，其血清抑制脾细胞对ＣｏｎＡ反应性低于正常血清，其胸腺（脾）细胞外液抑制胸腺细胞３Ｈ－ＴｄＲ自发掺入能力（脾细胞对ＣｏｎＡ反应性）也明显低于正常对照组，尤以ＭＷ＜１０ｋＤ组份为著；胸腺和脾细胞外液经ＳｅｐｈａｄｅｘＧ１００层析获得的第一峰较正常对照的高，而第二峰较之为低，其中第二峰对免疫功能的抑制作用低于正常对照的第二峰更为明显。结论：低剂量辐射能够改变免疫器官局部微环境，使免疫功能增强，可能与其神经体液因子等因素的变化有关。更多还原

【Abstract】 AIM and METHOD: To observe the effects of serum, thymocyte and splenocyte extracellular fluids(EFT, EFS)on immune functions 24h after whole-body irradiation with 75 mGy X-rays on Kunmin male mice. RESULTS:The inhibitory effect of irradiated murine serum on the response of the splenocytes to Con A was lower than that of normal murine serum, and the inhibitory effect of irradiated EFT(EFS)on thymocyte spontaneous proliferation(response of splenocytes to Con A), especially MW<10 kD fraction of EFT(EFS),was also lower than that of normal EFT(EFS). Irradiated EFT or EFS was divided into two protein peaks through the Sephadex G 100 filterThe first peak was higher and the second peak was lower than that of normal EFT of EFS, and the inhibitory effect of secondpeak on immune function was much lower than that of normal EFT or EFS. CONCLUSION: The local microenvironment of immune organs low dose radiation altered lead to the enhancement of immune functions may be related to the changes of neuro-humoral factors. .更多还原