【摘要】 目的：进一步了解胃粘膜幽门螺杆菌（ＨＰ）感染与癌前病变及胃癌发生的关系。方法：采用快速尿素酶法及免疫组化方法，检测１０５例不同程度胃粘膜病变活检组织中ＨＰ感染，ｐ２１、ｐ５３蛋白的表达。结果：（１）慢性萎缩性伴肠上皮化生性胃炎、不典型增生、胃癌ＨＰ感染率均显著高于慢性浅表性胃炎（Ｐ＜０．０１）。（２）ＨＰ阳性组ｐ２１阳性率（４９．１％）明显高于ＨＰ阴性组（１４．６％）（Ｐ＜０．０１），且ｐ２１蛋白表达率随着病变程度加重而升高。（３）检测ｐ５３突变体，ＨＰ阳性组慢性萎缩性伴肠上皮化生性胃炎、不典型增生及胃癌亦均显著高于慢性浅表性胃炎（Ｐ＜０．０１），且ＨＰ阳性组ｐ５３蛋白表达率（４２．６％）明显高于阴性组。结论：ＨＰ感染在癌前病变及胃癌病变过程中有重要的生物学意义。更多还原

【Abstract】 Objective:To make a further investigation into the relation between HP infection and gastric precancerosis and canceration.Methods: Rapid urease test and immunohistochemical method were used to detect the HP infection and expression of p21 and p53 in the biopsy tissues from 105 cases of gastric mucous lesion of different degrees.Results:The HP infection rate in the gastric cancer group with chronic atrophic concomitant intestinal gastritis or atypical hyperplasia was higher, compared with those with superficial gastritis (P<0.01). The p21 positive rate (49.1%) was evidently higher in the HP positive group than in the HP negative group (14.6%)(P<0.01), with an increase in the expression rate with the severity of the lesion. The p53 mutant variants, chronic atrophic concomitant intestinal gastritis, atypical hyperplasia and gastric cancer were detected to be obviously higher in the HP positive group than in the chronic superficial gastritis group (P<0.01), but the p53 expression(42.6%) was higher in the negative group.Conclusion: HP infection is biologically significant in gastric precancerosis and canceration.更多还原