【摘要】 <正>β-内酷胺类抗生素系临床应用最广的一类抗感染药物,主要包括青霉素G、半合成青霉素和头孢菌素类.目前我国一般医院常用品种约有20种.1980年以来,随着抗生素新品种的日益增多,我国临床不合理应用抗生素和药品不良反应(ADR)问题逐年加剧,从而导致浪费药品和医药费用逐年增高,使病人增加药源性疾病,甚至致残或致命.为此,我们查阅了近10年来国内主要药学期刊中有关本类药物的ADR报道53篇73例,加以综合分析,提出防治对策,以供临床合理用药参考和有关方面重视开展和加强ADR监察研究工作.更多还原

【Abstract】 β-Lactam antibiotics are most commonly used anti-infection agents in clinical practice. They mainly include penicillin G, semisynthetic penicillin and cephalosporins. About 20 varieties of cephalosporins are frequently used in China. Since 1980, with the introduction of more new antibiotics, the problems of irrational use and ADRs have become evident, and the problems have been resulting in waste of medical resources, increased cost of medical services, and medicamentous diseases, even disabilities and deaths. In view of this development, we collected 73 cases of ADRs induced by p-lactam antibiotics reported by 53 articles in domestic pharmacological periodicals and conducted a comprehensive analysis, with attempt to provide useful information for ADRs control.更多还原