【摘要】 以氯氮平作为电荷给体，７，７，８，８四氰基对二次甲基苯醌（ＴＣＮＱ）作为电子受体，用分光光度法研究了它们之间形成电荷转移（ＣＴ）络合物的条件。结果表明：在丙酮介质中，二者于４５℃水浴中恒温１ｈ即可形成１∶１的络合物，其最大吸收波长为７４３ｎｍ，０～１７５μｇ／ｍＬ范围内呈线性关系，表观摩尔吸光系数ε＝１６０×１０４Ｌ·ｍｏｌ－１·ｃｍ－１。方法的相对标准偏差小于１％（ｎ＝８）。对形成ＣＴ络合物的机理进行了探讨。应用拟定的方法对氯氮平片进行了含量测定，结果与标准方法一致，回收率为９９％。更多还原

【Abstract】 The charge-transfer(CT)complex formed between clozapine as the donor and 7,7,8,8Tetracyanoquinodimethane(TCNQ)as the acceptor in acetone has been studied by spectrophotometric method.Beer’s law is obeyed in the range of 0～175μg/mL of clozapine.The apparent molar absorptivity of CT complex at 743nm is 160×104L·mol-1·cm-1.The composition of CT complex is found to be 1∶1 by Bent-French,slope ratio and Job’s methods.The relative standard deviation is less than 1%(n=8).The method has been applied to the determination of clozapine in tablets with satisfactory results.Recovery has been found to be 99%.更多还原