节点文献
丙泊酚对大鼠脑突触体Na+,K+-ATP酶和Ca2+-ATP酶活性的影响
Effect of propofol on Na +, K + ATPase and Ca 2+ ATPase activities in rat cerebral synaptosomes in vivo
【摘要】 丙泊酚（ｐｒｏｐｏｆｏｌ）是一种新型短效静脉麻醉药，具有起效迅速，苏醒快，醒后无宿醉感等优点［１］，因而被广泛地应用于麻醉维持，但其全麻作用的确切机理仍不十分清楚．Ｎａ＋，Ｋ＋－ＡＴＰ酶对维持神经细胞的兴奋性，传导性和影响神经递质的释放等方面具有极为...
【Abstract】 Effect of propofol on Na +, K + ATPase and Ca 2+ ATPase activities of cerebral synaptosomes was investigated in rats. It was found that propfol 50 mg·kg 1 ip significantly inhibited Na +, K + ATPase activity of hippocampal and brain stem′s synaptosomes (P<0.01). Propofol 100 mg·kg 1 ip significantly reduced Na +, K + ATPase and Ca 2+ ATPase activity of cerebrocortical, brain stem′s and hippocampal synaptosomes (P<0.01). It is suggested that the central inhibitory effect of propofol may be related to the inhibition of Na +, K + ATPase and Ca 2+ ATPase activity of cerebral synaptosomes.
【Key words】 propofol； adenosine triphosphatase, sodium, potassium； adenosine triphosphatase, calcium； synaptosomes；
- 【文献出处】 中国药理学与毒理学杂志 ,CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY , 编辑部邮箱 ,1998年04期
- 【分类号】R971.2
- 【被引频次】11
- 【下载频次】93