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活血抗纤复方对鼠血清Ⅰ,Ⅲ型前胶原的调控作用
Quantitative Analysis of the Effects of Prunus Persica (LR) Batsob on Cytokine with Hepatic Fibrosis in Mice
【摘要】 采用放射免疫法(RIA)测定了活血抗纤复方对日本血吸虫性早期肝纤维化小白鼠体内血清中Ⅰ,Ⅲ型前胶原(ProcolegenTypeⅠ和ProcolegenTypeⅢ)的作用。结果表明:活血抗纤复方具有明显的降解PC-Ⅲ型纤维的作用,可以使胶原纤维明显减少,血清PC-Ⅲ含量显著下降(P<0.001);血清PC-Ⅰ型前胶原有所下降,但与对照组比较,无显著差异(P>0.05)。说明中药能有效地抑制实验动物血清中PC-Ⅰ型前胶原含量增加(P<0.05),但不能抑制血清中PC-Ⅲ型增加(P>0.05)。提示活血抗纤复方(桃仁水蛭煎剂)能有效地促进实验性肝纤维化的吸收与分解,具有临床应用价值。
【Abstract】 The effects of prunus persica (LR) batsob on quantitative analysis of PCⅠ and PCⅢ were studied by RIA in mice with schistosomiasis japonicum hepatic fibrosis.The results indicatedthatPCⅢintheexperimentalgroup was decreased than of control groups(P<0.01). No significant differences were shown between prunue persica(LR) batsob groups and control groups in the blood PCⅠ (P>0.05).This indicates,at least in part,the prunus presica(LR) batsob can increase collage fiber degradation.
【Key words】 liver fibrosis; RIA; prunue persica(LR) batsob; procollagen type I; procollagen type Ⅲ;
- 【文献出处】 武汉冶金科技大学学报 , 编辑部邮箱 ,1998年02期
- 【分类号】R285.6
- 【被引频次】2
- 【下载频次】24