【摘要】 缺血预适应是指心脏遭受短暂缺血后能耐受随后较长时间缺血损伤,是近年发现的一种预防心肌缺血损伤的有效措施。缺血预适应的心肌保护作用是心脏释放内源性心血管活性物质所介导。神经递质（儿茶酚胺、乙酸胆碱、降钙素基因相关肽、阿片肽等）可能是介导缺血预适应的内源性心肌保护物质。外源性应用神经递质能模拟缺血预适应的心肌保护作用。神经递质可同其它内源性活性物质相互作用。神经递质介导缺血预适应可能是通过与其相应受体结合,触发细胞内信息转导途径,激活蛋白激酶C产生心肌保护作用。更多还原

【Abstract】 Ischemic preconditioning has been defined as a tolerance of the myocardium to subsequent sustained ischemic damage after the heart was insulted one or more brief periods of ischemic stress. The cardioprotective effect of ischemic preconditioning may be mediated by endogenous cardiovascular active substances. Neurotransmitters, including catecholamines, acethylcholine, calci-tonin gene-related peptide and opioids, may be endogenous myocardial protective substances, and participate in the mediation of ischemic preconditioning. Exogenous administration of neurotrans-mitters can mimic the cardioprotective effect of ischemic preconditioning. There is interactions of some neurotransmitters with other endogenous active substances. The mechanism by which neurotransmitters are involved in the cardioprotective effect of ischemic preconditioning is thought to activate their corresponding receptors, with a subsequent triggering cellular signaling pathway, resulting in myocardial protection.更多还原