【摘要】 细胞在其ＤＮＡ受损时，利用“关卡控制”阻断细胞周期的进行，以便于对受损的ＤＮＡ进行修复，避免了突变的产生．此外，在多细胞生物中，ＤＮＡ的严重损伤还会诱发细胞凋亡，以个别ＤＮＡ受损细胞的死亡为代价保护机体遗传信息的稳定性．在上述过程中，两种人类抑癌基因———Ｐ５３和ＡＴＭ基因的产物发挥着重要作用．更多还原

【Abstract】 Cellular responses to DNA damage includ checkpoint controls to arrest the cell cycle,allowing repair to take place before mutation can be perpetuted.And in multicellular organisms,DNA damage can also induce apoptotic cell death,protecting the organism at the expense of the individual cell death.In the cellular choice between cycle control and cell death,two human tumour suppressor proteins P53 and ATMgene product play an important role.更多还原