【摘要】 采用同位素示踪、细胞周期分析和组化等技术，研究Ｃｅ３＋和Ｇｄ３＋对动物正常二倍体细胞的生物学作用。结果表明，Ｃｅ３＋和Ｇｄ３＋仅在一个狭窄的剂量范围（１×１０－６～１×１０－５ｍｏｌ／Ｌ）可促进正常二倍体细胞增殖，有明显的剂量—效应关系。Ｃｅ３＋和Ｇｄ３＋在高浓度时（１×１０－３ｍｏｌ／Ｌ），对细胞具有毒性，可使细胞坏死、增殖缓慢并诱导细胞凋亡。更多还原

【Abstract】 The biological effect of Ce and Gd diploid cell in vitro was evaluated with isotopic tracing method, flow cytometry and cytochemistry techniques. Experimental results show that Ce and Gd at a narrow concentration field(1×10 -6 ～1×10 -9 mol/L) promotes cell proliferation, and that there is a striking dose effect relationship. Gd and Ce also have cellular toxicity at high concentration(1×10 -3 mol/L), which cause cell necrosis, slow in cell proliferaton and induce cell apoptosis.更多还原