【摘要】 目的:为了解健康人体内凝血活性状态,确定尿纤维蛋白肽A(FPA)的正常参考水平。方法:采用高效液相色谱法(HPLC)定量检测60例健康人24小时尿纤维蛋白肽A(FPA)水平。结果:健康人24小时尿FPA从水平为59.3±27.1μg/24小时,不同年龄、性别或日内各时段间尿FPA水平无显著性差异。结论:健康人尿中含徽量FPA,其水平不受年龄、性别等因素的影响,认为单次晨尿FPA检测可取代24小时尿FPA总量检测。本研究结果为临床上研究某些伴随凝血系统紊乱的疾病提供了一个较为可靠而稳定的尿FPA正常参考指标。更多还原

【Abstract】 Objective:To provide a normal reference value of urinary fibrinopepnde A (uFPA) for exploring the changes of the states of the coagultive activation in some diseases. Method;the uFPA levels of 60 healthy persons was determinated by High performance Liquid chroraatography (HPIC) assay. Results: The uFPA levels of 60 healthy persons was 59.3 ± 27.1 μg/24h. No significant difference was found in various age groups and also NO significant difference between the male and the feamle. In 4 time segements during one 24 - hours almost same amount of uFPA was detected. Conclusion:It showed that in normal individuals, uFPA was not affected by age or sex and was excreted at stable rate in 24 hours. so uFPA is a reliable and stable normal index of reflecting coagulative activation and 24 - hour urine collection can be replaced by single morning urine sampling.更多还原