【摘要】 用ＨＰＬＣ法测定在加了不同浓度硝氯酚和丙硫咪唑的Ｒ氏液中体外培养的肝片吸虫体内γ＿氨基丁酸（ＧＡＢＡ）的含量，结果证实硝氯酚能极显著地降低肝片吸虫体内ＧＡＢＡ含量，丙硫咪唑对肝片吸虫体内ＧＡＢＡ含量无显著性影响，硝氯酚的抗肝片吸虫作用可能与ＧＡＢＡ有关，丙硫咪唑的抗吸虫作用可能与ＧＡＢＡ无关。更多还原

【Abstract】 The levels of γ_aminobutyric in F.hepatica incubated in Rohrbacher solution added different concentrations of niclofolan and albendazole were determined by reverse_phase HPLC by precolumn fluorescence derivalization with θPA_β_ME.The level of GABA in F.hepatica incubated in niclofolan was reduced significantly,the mode of actiond of niclofolan is probably relative to GABA.Incubation of the flukes in albendazole resulted in no significant change in the level of GABA,this result suggested that the mechanism for the fasciolicidal activity of albendazole has no relation with GABA.更多还原