【摘要】 目的:研究芳烃羟化酶(AHH)与吸烟在肺癌易感中的作用。方法:采用 AHH 直接测定法,检测肺癌患者40例、肺癌患者亲属26例及健康人45例血液淋巴细胞中 AHH 的诱导力。结果:①吸烟者中,肺癌患者 AHH 高、中、低诱导力者分别与不吸烟对照组相比有高度显著性差异(P<0.001,P<0.03,P<0.001)。②肺癌患者亲属(一级亲24人,二级亲2人)吸烟者中 AHH 低诱导力者与不吸烟对照组相比有增多趋势(P=0.18);不吸烟 AHH 高诱导力者同样有增多趋势(P=0.2)。结论:吸烟会引起肺癌患者体内的 AHH 诱导力明显升高,那些 AHH 高诱导力型的人,加上长期大量吸烟易患肺癌。更多还原

【Abstract】 Objective:To investigate the role of aryl hydrocarbon hydroxylase (AHH) and smoking in susceptibility to lung cancer.Method:AHH inducibility in lymphocyte has been measured in 45 healthy individuals,40 patients with lung cancer and 26 relatives of them.Results:①AHH high,intermediate,low inducibility of smokers in lung cancer patients were significantly higher (P<0.01,P<0.03,P<0.001) than in controls of smoker.② AHH low induibility of the smokers in relatives of lung cancer patients (first degree 24,second degree 2) was in- creased obviously compared with the nonsmoker in controls (P=0.18);AHH high inducibility of the nonsmokers in relatives was increased,too (P=0.2).Conclusions:AHH inducibility of the smokers in lung cancer patients were increased significantly.AHH high inducibility of the smokers have genetic susceptibility to lung cancer.更多还原