【摘要】 目的:研究麦冬多糖对正常和实验性糖尿病小鼠血糖的影响。方法:昆明种小鼠40只,分成4组,分别用麦冬多糖(100和300mg/kg)、优降糖(2.5mg/kg)和等体积生理盐水(2ml/只)灌胃,测定各组正常小鼠的血糖水平及以葡萄糖(2g/kg)、四氧嘧啶(70mg/kg)、肾上腺素(0.02mg/kg)所致小鼠高血糖模型的血糖水平。结果:剂量为100和300mg/kg的麦冬多糖灌胃对葡萄糖、四氧嘧啶及肾上腺索引起的小鼠高血糖均有抑制作用,对正常小鼠的血糖亦有降低作用。结论:麦冬多糖对正常和实验性糖尿病小鼠的血糖有明显的抑制作用。更多还原

【Abstract】 OBJECTIVE: To study the effect of polgsaccharide from ophiopogonis tuber (POT) on blood sugar in normal and experimental diabetic mice. METHODS: Forty mice were divided into four groups and each group was raised with POT(100,300mgAg),glybenzcyclamide(2.5mg/kg) and NS(2ml/mice),respectively.The levels of blood sugar were calculated in normal and in experimental hyperglycemias induced by glucose (2g/kg), adrealin(70mg/kg) and alloxam (0.02mg/kg).RESULTS:In addition to the decrease of blood sugar in normal mice,POT at doses of 100,300mg/kg was also found to decrease various experimental hyperglycemias induced by glucose,adrealin and alloxam.CONCLUSION:POT had significant antagonistic effect on the experimental hyperglycemias in normal and intoxicated mice.更多还原