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复方黄芩制剂抗大鼠肝纤维化作用
Anti-hepatofibrotic effect of compound scutellaria liquid extract in rats
【摘要】 目的:研究复方黄芩制剂抗肝纤维化的作用。方法:采用皮下注射CCl4和营养控制两因素致大鼠肝纤维化模型,从组织病理学和组织化学两方面进行现察。结果:复方黄芩制剂ig给药,5~10g/kg能明显减轻大鼠纤维化程度(P<0.01)。结论:复方黄苓制剂具有显著的抗肝纤维化作用。
【Abstract】 OBJECTIVE: To study the anti-hepatofibrotic effects of compound scutellaria liquid extract (CSLE). METHODS:Hepatic fibrosis model was induced by CCl4 and nutrition restriction in rats. The severity of fibrosis was assessed with histopathological and histochemical examination. RESULTS: CSLE markedly reduced the degree of hepatic fibrogenesis when it was given ig 5 - 10g/kg to the model rats. CONCLUSION: CSLE was proved to have significant anti -hepatofibrotic effect.
【关键词】 复方黄芩制剂;
联苯双酯;
肝纤维化;
四氯化碳;
【Key words】 compoud scutellaria liquid extract; biphenyldicarboxylate; hepatic fibrosis; CCl4;
【Key words】 compoud scutellaria liquid extract; biphenyldicarboxylate; hepatic fibrosis; CCl4;
【基金】 浙江省自然科学基金资助项目第394210号
- 【文献出处】 中国现代应用药学 ,Chinese Journal of Modern Applied Pharmacy , 编辑部邮箱 ,1998年04期
- 【分类号】R285.5
- 【被引频次】2
- 【下载频次】66