【摘要】 分别用部颁试标、部颁正标和以人工肠液为溶出介质的浆法测得尼莫地平片的溶出度,分别与其体内的生物利用度进行相关性研究。结果表明,按部颁试标测定的溶出度与生物利用度呈无显著性负相关,按部颁正标测定的溶出度与生物利用度呈无显著性正相关,而若采用人工肠液为溶出介质,则所得溶出度与生物利用度呈显著的正相关,即采用人工肠液为溶出介质最为合理。更多还原

【Abstract】 The in vitro dissolution of nimodipine tablet was determined with the design of Chinese WS - 148(x - 96) -91,the design of WS1 - (x - 100) - 95Z and paddle method with simulated intestinal fluid TS as dissolution medium respectively,and the results were compared with its bioavailability respectively. As a result, the former two designs were demonstrated unfit, while the latter one is relatively fit.更多还原