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肺心营养合剂预防大鼠应激性高血压的研究

Prevention of Stress-induced Hypertension by a Mixture of Nutrients (PX) in Rats

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【作者】 严米娅; 余上斌; 金咸瑢;

【Author】 Yan Miya; Yu Shangbin; Jin Xianrong(Department of Pathophysiology, School of Basic Medical Sciences,Tongji Medical University, Wuhan 430030)

【机构】 同济医科大学基础医学院病理生理学教研室!武汉; 430030;

【摘要】 研究了肺心营养合剂(PX)对应激性高血压大鼠血流动力学的影响。结果PX灌胃28d后固定悬吊复制应激性高血压的大鼠(PH组)与生理盐水灌胃28d后固定悬吊复制应激性高血压的大鼠(NH组)比较,PH组的舒张压(DP)和平均动脉压(MAP)均明显低于NH组(P<0.05),脉压(PP)则明显大于NH组(P<0.05)。其收缩压(SP)较低,心输出量略高,但差异无显著性意义(分别为P>0.1,P>0.25)。PH组的SP略高于正常血压大鼠(NC组)(P<0.05),而PP明显大于NC组(P<0.01)。结果表明PX有抗高血压的作用,尤其是对舒张压的影响更为明显。

【Abstract】 The effect of a mixture of nutrients (PX) on hemodynamics in hypertensive rats was studied.High blood pressure was induced by fixing and hanging. The rats were divided into 4 groups: group hypertension (H), group hypertension pretreated with PX for 28d by gastrogavage (PH), group hypertension pretreated with normal saline for 28 d by gastrogavage (NH), and normal control group (NC). The resultsshowed that the diastolic blood pressure (DP) and mean arterial blood pressure (MAP) of group PH were significantly lower and the pulse pressure(PP) higher than those of group NH (P<0. 05). Although the systolic blood pressure seemed lower and the cardiac output higher in group PX than in group NH, there was nostatistical significance. The PP of group PH was also higher than group NC (P<0. 01 ). The results revealthat this mixture of nutrients has an inhibitory effect on high blood pressure especially on the diastolic bloodpressure.

【关键词】 营养素; 应激; 高血压;
【Key words】 nutrient; stress; hypertension;
【基金】 湖北省重点科技计划项目!(93)014
  • 【文献出处】 同济医科大学学报 ,ACTA UNIVERSITATIS MEDICTNAE TANGJI , 编辑部邮箱 ,1998年04期
  • 【分类号】R544.1
  • 【被引频次】8
  • 【下载频次】58
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