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多烯脂肪酸药理研究概述

Generalization of pharmacological studies on polyenic fatty acids (PUFA)

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【作者】 谢克勤陈丽宇

【Author】 Xie Keqin and Chen Liyu (Institute of Medical and Pharmaceutical Science Tianjin, Tianjin 300070)

【机构】 天津市医药科学研究所!天津300070

【摘要】 概述多烯脂肪酸对肿瘤和缺血性疾病的作用及机理。廿碳五烯酸、廿二碳六烯酸及其n-3同系物,在动物实验和临床试验中,具有降低血脂、甘油三酯、总胆固醇作用,提高高密度脂蛋白、降低血粘度、减少血小板聚集和血栓形成作用,以及防止冠心病猝死及抗肿瘤作用。

【Abstract】 Relations and active mechanisms of PUFA with neoplasma and ischemic disease were reviewed. In animal experiments and clinical tries, it was shown that eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA) and their analogs (n-3 PUFA) could lower the lipide,triglyceride and total cholesterol in blood,raise high density lipoprotein,reduce bldri viscority,depress platelet aggregation,delay formation of thrornbus,and protect from sudden coronary death,also could inhibit several tumor growth.

  • 【分类号】R96
  • 【被引频次】18
  • 【下载频次】100
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