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甲基磺酸甲酯和环磷酰胺抑制小鼠精子的受精能力

Inhibition of Fertilizability by MMS and CY in Mouse Sperm

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【作者】 张燕林; 蒋秀蓉; 王仁礼; 张忠恕; 游根娣;

【Author】 Zhang Yan - lin, Jiang Xiu-rong, Wang Ren-li Zhang Zhong - shu, You Gen - di(Shanghai Institute of Planned Parenthood Research,Shanghai ,200032) ( Shanghai Institute of Materia Medica,Chinese Academy of Sciences,Shanghai, 200031)

【机构】 上海市计划生育科学研究所!上海200032; 中科院上海药物研究所!上海200031;

【摘要】 本文应用小鼠卵子体外受精的方法,研究了诱变剂甲基磺酸甲酯和环磷酰胺对小鼠精子受精能力的影响.结果显示,以上两种诱变剂能明显抑制小鼠精子的受精能力,与对照组相比有显著性差异(P<0.01),同时受精后的胚胎发育延缓,但对精子的活力和密度无明显影响.

【Abstract】 The aim of the study is to evaluate the effects of mutagens MMS and CY on fertilizing ability of mouse sperm in vitro. The results showed that compared to controls, the fertilizing ability of sperm in mouse treated with MMS or CY was remarkably inhibited (P<0. 01). It was also observed that the embryonic development was delayed in the treatment group, but no significant changes in spermatozoa concentraction and activity were found.

【基金】 国家自然科学基金(39370710)资助
  • 【文献出处】 生殖与避孕 ,Reproduction and Contraception , 编辑部邮箱 ,1998年03期
  • 【分类号】R965
  • 【下载频次】65
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