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乙酸经皮局部注射治疗小鼠肝癌的实验研究

The Study of the Effect of Ethyl-acid in Liver Carcinoma in Mice

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【作者】 张岚郑振辉刘东玉董轶武弼东

【Author】 Zhang Lan \ Zheng Zhenhui\ Liu Dongyu\ Dong Yi \ Wu Bidong (China-Japan Friendship Hospital , Beijing 100029)

【机构】 中日友好医院

【摘要】 使用两种浓度乙酸经皮局部注射治疗小鼠肝癌(H22)。分别采用15%、30%浓度的乙酸进行瘤内注射硬化治疗,发现30%浓度组效果更好,各浓度组均未发现对动物体的明显毒副作用,与无水乙醇治疗组相比无显著差异。提示在经皮局部注射治疗肝癌时,对无水乙醇不适合的患者,可采用30%乙酸

【Abstract】  For studying the effect of ethyl-acid in the liver carcinoma inmice, 32 NIH mice (body weight 18~22 g,with liver carcinoma)were divided into 4 groups. Injected with ethyl-acid (15 % and 30 %),anhydrous ethanol locally and percutaneusly, normal saline as control. There is significant difference in the volume of livercarcinoma between study and control groups (P<0.01). There is difference in the weight of liver carcinoma between study and control groups(P<0.05).There are no differences between the three study groups(P>0.05). It showed that There is effect of ethyl-acid in the therapy of the liver carcinoma in mice. 

  • 【文献出处】 实验动物科学与管理 ,LABORATORY ANIMAL SCIENCE AND ADMINISTRATION , 编辑部邮箱 ,1998年04期
  • 【分类号】R-332,R735.7
  • 【被引频次】5
  • 【下载频次】14
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