【摘要】 再狭窄是血管成形术的主要远期并发症。本研究结合内皮拉伤及高脂饮食诱导家兔髂动脉粥样硬化性狭窄，在此基础上行血管成形术，模拟血管成形术后再狭窄的病理过程，以建立再狭窄的实验动物模型。结果发现，本模型的基础病变、血管成形术前后表现及再狭窄的形成等均与人体的相应过程基本一致。表明本模型是研究血管成形术后再狭窄过程的理想模型更多还原

【Abstract】 Restenosis was the main long-term complication of vascualr angioplasty ,By combining both endothdlial injury and hypercholesterol diet, we induced rabbit iliac aretry atherosclerotic stenosis and accomplished angioplasty on it. Thus, we mimiced the pathologcal process of restenosis after vacular angioplasty and made an annimal model of it . We found that the basic lesions, the manifestation before and after angioplasty and formation of restenosis were all similar to that of humanbeings. We concluded that this animal model was satisfactory and could be used to investigate the prcess of restenosis after angioplasty.更多还原