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白介素-2诱发大鼠低血压及其机制探讨

Study on Mechanism of Hypotension Induced by rIL-2 in Rats

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【作者】 涂自智陈广文罗涵邓恭华尤家騄

【Author】 Tu Zizhi,Chen Guangwen,Luo Han et al (Hunan Medical Univerity,Changsha 410078)

【机构】 湖南医科大学病生教研室!长沙410078

【摘要】 用国产重组人白介素-2(rhIL-2)复制大鼠低血压模型并探讨其机制。24只wistar大鼠随机分成3组(每组n=幻:正常对照组,IL-2实验组(rhIL-2)和氨基胍(AG)治疗组。结果显示:IL-2可使大鼠提睾肌微动脉扩张及MAP下降,肺、肾、肝组织Evan’sBlue含量明显增加。AG可使rhIL-2引起的低血压回升,微动脉缩小,肺组织Evan’sBlue含量明显下降。提示rhIL-2引起低血压,可能与IL-2诱导NO产生,使血管扩张及通透性增加有关。

【Abstract】 The mechanism of hypotension induced by rhIL-2 was studied in rat modelestablished by the authors. 24 Wister rats were randornly divided into 3 groups: (1) normalcontrol; (2)rhIL-2; (3)rhIL-2 plus andnoquanidine (AG). The result showed that,comparedwith group (1),significant dilation of cremasteric arteriole and decrease of mean arterial pressure (MAP) were observed in group(2),and the contents of Evan’s Blue in lung,kidney andliver tissues were significantly increased. However, in group (3),the elevation of blood pressure and shrink of arteriole diameter were observed,and the content of Evan’s Blue in lungtissue was significantly decreased. It indicated that the hypotension dright be related to theinduction of NO by rhIL-2.

【关键词】 白介素-2低血压氨基胍
【Key words】 rhIL-2HypotensionAminoquanidine
  • 【文献出处】 中国生物制品学杂志 ,CHINESE JOURNAL OF BIOLOGICALS , 编辑部邮箱 ,1998年03期
  • 【分类号】R730.5
  • 【被引频次】3
  • 【下载频次】29
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