【摘要】 对我国首次研究成功的伤寒Vi多糖菌酋进行了人体接种安全性、反应性、血清学效果和流行病学效果观察，各期观察达21万余人，结果证实伤寒Vi多糖茵茵安全世良好，反应轻微。血清学效果显示，30μg一次免疫，Vi抗体4倍增长可达91．6％。两次流行病学效果考核，按血培养伤寒杆菌阳性病例统计，保护率可达70％左右，茵茵的效果指数为3．29～3．49。该菌苗性质稳定，初免只需注射一针，替代现行菌体菌苗推广应用是完全可行的。更多还原

【Abstract】 The safety,reactivity,serological and epidemiological efficacy of Salmonellatyphi Vi capsular polysaccharide vaccine were studied in more than 210,000 volunteers.Theresult showed good safety and mild reaction of the vaccine.The Vi antibody level increasedby 4-folds in 91.6% of the volunteers after being immunized with one dose(30μg)of thevaccine.According to the result of blood sample cultrue for Salmonella typhi,the protectiverate of the vaccine reached about 70%,and the efficacy index of it was 3.29～3.49.The vaccine was stable and only a single dose is required for primary immunization.So it might bewidely used as a substitute for current Salmonella typhi whole cell vaccine.更多还原