【摘要】 目的研究有机磷农药的心脏毒性，探寻合理的治疗措施。方法大鼠用五种常用的有机磷农药乐果、敌百虫、马拉硫磷、甲胺磷和对硫磷染毒中毒后，观察心电图随中毒时间的变化。结果有机磷农药中毒确实引起大鼠的心电图改变，常见者为Ｓ－Ｔ期间延长，Ｒ波及Ｔ波的波幅改变，Ｐ－Ｒ期间改变等等，提示有机磷农药中毒有心脏损害。心电图改变与有机磷农药的品种、给予剂量及所处中毒过程的时相有关。结论有机磷农药可以引起心脏损伤，致心电图表现随农药、中毒时程而不同。这有助于对临床报告的中毒病人不同心电图表现的理解。建议在治疗有机磷农药中毒过程中，对心脏损害给予足够的关注，并采取相应的措施更多还原

【Abstract】 o　study　the　cardiac　toxicity　of　common　used　organophosphorus　pesticides　and　deduce　more　rational　clinical　treatment,the　timecourse　alteration　of　ECG　in　intoxicated　rats　with　five　common　used　organophosphorus　pesticides,Dimethoate,Trichlorfon,Malathion,Methamidophos,Parathion　were　observed.The　results　showed　that　these　five　organophosphorus　pesticides　could　do　induce　the　alterations　of　EKG　in　rats.The　common　findings　were　the　prolongation　of　ST　interval,the　change　of　amplitude　of　Rand　Twave,and　the　variation　of　PR　interval　in　the　mild　intoxicated　rats,additionally,the　abnormal　waves　might　appear　in　the　severe　cases,indicating　that　organophosphorus　pesticides　could　induce　cardiac　damages.The　ECG　alterations　were　related　with　the　type　of　organophosphorus　pesticides,the dosage　and　timecourse　of　intoxication.Therefore,the　study　is　helpful　to　understand　the　variety　of　ECG　during　organophosphorus　pesticides　intoxications.It　is　suggested that　much　more　attention　should　be　paid　on　the　cardiac　damages　and　the　aimed　measures　should　be　given　during　the　intoxication　of　organophosphorus　pesticides.更多还原