节点文献

硒、锌、钼对汞中毒拮抗作用的比较

Comparison of Antagonistic Effects of Se、Zn and Mo on Mercury Intoxication in Mice

  • 推荐 CAJ下载
  • PDF下载
  • 不支持迅雷等下载工具,请取消加速工具后下载。

【作者】 连祥霖林嗣豪

【Author】 Lian Xianglin,Lin Sihao.Department of Occupational Health,Fujian Medical College,Fuzhou 350004

【机构】 福建医学院劳动卫生学教研室

【摘要】 为了探讨微量元素对汞中毒的拮抗作用,用氯化汞制备小鼠汞中毒模型,使其发生明显脂质过氧化损伤,经硒、锌、钼预处理后再给同剂量氯化汞,可降低汞中毒鼠的死亡率,肝、肾、脑组织中脂质过氧化物含量明显降低,超氧化物歧化酶活性相应增高(P<0.01)。提示硒、锌、钼能拮抗汞引起的致死作用和脂质过氧化作用,其拮抗强度依次为钼>锌>硒。这为汞中毒防治提供新的途径。

【Abstract】 o study the effects of trace elements on mercury intoxicution in mice,mercury poisoning mode was prepared with HgCl2 in mice that induced obvious lipid peroxidation damage.After pretreament with Se、Zn and Mo respectively,the mortalities of mercury poisoned mice were decreased,the contents of the LPO products in livers,kidneys and brains of poisoned mice were reduced,and the activity of SOD was increased(P<001).It is suggested that Se、Zn and Mo might have antagonistic effect against the mortalities and lipid peroxidation caused by mercury.The intensity of antagonism seems Mo>Zn>Se.The results supply a new way in prophylaxis and treatment of mercury poisoning..

  • 【文献出处】 中国工业医学杂志 ,CHINESE JOURNAL OF INDUSTRIAL MEDICINE , 编辑部邮箱 ,1998年01期
  • 【分类号】R135.13
  • 【被引频次】15
  • 【下载频次】130
节点文献中: 

本文链接的文献网络图示:

本文的引文网络