【摘要】 目的：探讨发作间期１８Ｆ脱氧葡萄糖（ＦＤＧ）正电子发射断层扫描（ＰＥＴ）和９９ｍＴｃ已撑半胱氨酸（ＥＣＤ）单光子发射断层扫描（ＳＰＥＣＴ）对难治性颞叶癫痫（ＴＬＥ）的定位诊断价值。方法：５３例脑电图（ＥＥＧ）定位明确的难治性ＴＬＥ患者分别行发作间期１８ＦＦＤＧＰＥＴ和９９ｍＴｃＥＣＤＳＰＥＣＴ检查。其中２１例磁共振（ＭＲＩ）显示有结构性病变并与ＥＥＧ定位结果一致。结果：ＭＲＩ异常组均在ＰＥＴ和ＳＰＥＣＴ相应部位出现低代谢和低灌注表现。ＭＲＩ正常组，ＰＥＴ定位准确率为８４％，显著高于ＳＰＥＣＴ的５６％（Ｐ＜００５）。结论：对于无结构性病变的颞叶癫痫，发作间期ＰＥＴ检查有较高的定位诊断价值，ＳＰＥＣＴ的临床意义相对较小。更多还原

【Abstract】 Objectives:To study the clinical value of interictal ¹⁸FFDG positive emission tomography （PET） and ^99mTcECD single-photon emission computed tomography （SPECT） in the detection of temporal epileptic foci. Methods: ¹⁸FFDG PET and ^99mTcECD SPECT in 53 patients with intractable temporal epilepsy confirmed by clinical characteristics and interictal and ictal scalp EEG were performed. Of 53 patients 21 showed structural abnormality detected by MRI, which was identical with EEG determination. Results:It was noted that, in patients with abnormality by MRI, hypometabolism and hypoperfusion appeared in the corresponding area on PET and SPECT. However, the accuracy rate of the localization in patients with normal MRI was 84.5% apparently higher than that on SPECT（56.3%,P<0.05）Conclusions:It was concluded that¹⁸FFDG PET might be a valuable tool for accurate localization of epilepsy with no structural abnormality and SPECT be of less significance.更多还原