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复方炉甘石洗剂助悬剂的筛选

THE SELECTION OF SUSPENDING AGENTS OF CALAMINE LOTION

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【作者】 陈文; 王鲁石; 许玉华; 韩娟; 郭杰; 郑新建; 王新春;

【Author】 Chen Wen et al(Department of Pharmaceutics,Shihezi Medical college, Xinjiang 832002)

【机构】 石河子大学医学院药学系; 石河子大学医院; 石河子医学院一附院;

【摘要】 本实验采用正交实验设计的方法考查了炉甘石洗剂采用3种常用助悬剂和一种润湿剂对其稳定性的影响,结果表明,助悬剂羧甲基纤维素纳(CMC-Na)、淀粉、枸橼酸钠对炉甘石洗剂的稳定性有极显著影响,交互作用结果表明CMC-Na与淀粉合用对洗剂稳定性有极显著影响,吐温-80对稳定性无影响,综合分析得最佳水平为淀粉、CMC-Na、枸橼酸钠用量分加为0.8%,0.6%,1%和0.5%(g/100ml).

【Abstract】 Three suspending agents and one wetting agent effected the stability of suspensions were studied by the orthogonal designed experiments. The results showed that the effect of stability by added CMC-Na of sodium citrach and starch were obviously different. But the tween-80 was no effect to the stability. An optimal concentration of CMC- Na,starch and sodium citrate were 0. 8 % 0.6% and 1% respectively

  • 【文献出处】 农垦医学 ,AGRICULTURAL RECLAMATION MEDICINE , 编辑部邮箱 ,1998年01期
  • 【分类号】R944
  • 【被引频次】3
  • 【下载频次】326
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