【摘要】 目的：探讨睾丸粘膜相关淋巴瘤的临床病理特征，为临床早期诊断提供依据。方法：对4例睾丸粘膜相关淋巴瘤作临床病理观察，同时采用SP法或ABC法进行LCA、L26、UCHL1、bcl-2免疫组化标记。结果：本组4例病人平均年龄为65.25岁。临床主要症状除有睾丸不同程度肿大外.无其他特异性的阳性发现。组织学上与胃肠道MALT-oma相似。1例转化为高度恶性MALT-oma。免疫组化结果显示瘤细胞表达LCA、L26和bcl-2。结论：老年人出现睾丸弥漫性肿大，首先应考虑睾丸淋巴瘤的可能。本病的确诊依赖病理诊断，免疫组织化学方法对于鉴别诊断有重要作用。更多还原

【Abstract】 Objectives: To investigate 4 cases of primary testicular malignantlymphoma of mucosa associated lymphoid tissue (MALT-oma), analyze their clinical manifestations and pathological features and improve the clinical early diagnosis of testicular MAI-T--oma.Methods: Histopathological method was used to study the morphological characteristics of MALT-oma of testis. The immunohistochemical determination of LCA 、L26、UCHL1 、bcl-2 protein of the routine paraffin samples of 4 cases with testiculr MALT--oma was carried out using SP or ABC method. Results: The average age of the patients was 65. 25 years. The main presenting symptom was swollen testis without other specific findings. Histologically ,they were all diffuse non--Hodgkin’s lymphoma. The histological characteristic of testicular MALT--oma are similar to gastrointestine MALT--oma. The results of immunohistochemistry showed that the lymphoma cells were derived from B-lymphocyte. LCA, L26 and bcl-2 were positive in MALT--oma of testis. Conclusions: When a diffuse mass of a testis occurs in a patient with old age, the possibility of lymphoma should be considered first. The definite diagnosis of the disease depends on the pathological examination, and immunohistochemistry plays an important role in differential diagnosis.更多还原