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麻风在FD MDT后复发的危险性

Risk of Relapse Following FD MDT in Leprosy

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【摘要】 在1986~1995年间,于云贵川三省59个县共8,307名麻风病人完成了 FD MDT,之后每年进行监测;平均复发率在 MB 是0.15/1000人年,PB 0.55/1000人年。FD MDT 前的未治组与经治组的复发率没有显著差异。MB 中5名复发出现在监测的第4~7年;5名 PB 复发在 FD MDT 后的4~5年。另有6名 PB 在5年监测期后复发,未计算在复发率中。PB 复发中,多数(6/11)是原本应上 MB 方案,却上了 PB 方案,治疗不充分;有8例(8/11)复发转型为 MB。在62名治疗不规则的 MB 中有4人复发(6.5%)。

【Abstract】 During 1986 to 1995,8307 leprosy patients(MB 598 and PB 2326)had com- pleted their fixed duration MDT and then follow-up was done annually in five successive years in 59 counties of Yunnan,Guizhou and Sichuan.Among them the mean relapse rate was 0.15 per 1000 person-years in MB and 0.55 per 1000 person-years in PB.There was no difference between the relapse rates of those who received DDS or DDS plus RMP(5111)and not(3196) before FB MDT.Five relapsed MB cases occurred 4 to 7 years after stop of the treatment and five PB cases relapsed 4 to 5 years after stopping the drugs.Other six relapsed PB cases occurred after five-year follow-up duration and were not calculated in the relapse rate.The majority of re- lapsed PB cases(6/11)should originally be given MB regimen but used PB one,and so,the treatment was not enough for them.There were eight PB cases to have become MB after relapse. Among 62 MB cases with irregular treatment four cases relapsed,being 6.5%.

【关键词】 MDT麻风复发率
  • 【分类号】R755
  • 【被引频次】7
  • 【下载频次】21
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