【摘要】 目的：研究凋亡诱导基因Fas基因与正常妇女子宫内膜周期性变化的关系。方法：用免疫组化ABC法检测了40例月经周期各时限子宫内膜组织中Fas基因蛋白的表达情况。结果：Fas基因蛋白在增生期子宫内膜中的表达评分（149．2±87．8）明显低于分泌期子宫内膜中Fas蛋白的表达评分（251．8±63．7）；Fas蛋白在增生早期子宫内膜中表达评分（210．0±52．9）明显高于增生晚期子宫内膜中的表达评分（99．5±79．8），（P＜0．01）；Fas蛋白在分泌早期子宫内膜中表达评分（260．6±66．8）与分泌晚期子宫内膜表达评分（244．5±63．4）无显著性差异，（P＞0．05）。结论：Fas基因蛋白的表达可能参与了子宫内股的周期性变化过程。更多还原

【Abstract】 To study the relationship between the expression of Fas and the periodic changeof normal endometriun during the menstrual cycle. Methods: The Fas expression in 40 cases of noumal endometrium during the menstrual cycle was determined with immunohistochemical methods (ABC). Wilcoxon statistical analysis was peiformed. Results: The fas expression score was 149. 2 ±87. 8 in prolifertive endometrium, 251. 8 ±63. 7 in secretory endometrium; 210.0 ±52. 9 in early proliferative endometrium; and 99. 5 ±79. 8 in late proliferative endometrium; there were significantly statistical differences(P＜ 0. 01 ). The score in early secretory endometrium (260. 6 ±66. 8)was not significantly higher than thatin late secretory endometrium (244. 5±63. 4) (P＞ 0. 05). Conclusion: Fas expression plays an importantrole in the apoptosis of the normal endometrium durig the menstrual cycle.更多还原