【摘要】 目的为探讨白细胞介素（Interleukin，IL）－8在慢性肺心病中的意义及与病情的关系。方法用ELISA方法动态观察了30例慢性肺心病患者血清IL-8水平。结果慢性肺心病患者急性加重期血清IL－8水平明显高于缓解期及正常对照（P均＜0．01），而患者在缓解期血清IL－8水平仍高于正常对照（P＜0．01）；心功能Ⅲ－Ⅳ级患者血清IL－8含量又明显高于心功能Ⅱ级患者（P＜0．01），且在急性加重期，患者血清IL－8含量与动脉血气中PaO₂和pH值均成明显的负相关性，（r分别为-0．429和-0．613，P分别＜0．02和0．01），而与PaCO₂成正相关性（r=0．889，P＜0．01）。结论IL－8可能参与了慢性肺心病的发病过程，测定血清IL－8水平，对估测慢性肺心病患者的病情轻重有一定意义。更多还原

【Abstract】 Objective To investigate the potential significanse of levels of serum interleukin (IL)-8 in chronic ocr pulmonale secondary to chronic obstructive pulmonary diseases (COPD). MethodThe levels of serum IL - 8 in 30 patients with chronicocr pulmonale and 30 normal subjects were serialymeasured by ELISA. Results The results showenthat seam IL- 8 level in the patients during acutephase significantly higher than that in the normaloontrols, and in the patients during recovery phaseP < 0.01 ). Meanwhile, the levels of serum IL- 8 inthe patients during recovery phase were significantlyhigher than that in the noeds (P < 0.01 ). In addition, the levels of serum IL- 8 in 20 patients with Ⅲ～Ⅳ degree heart failure during acute phase weresignificantly higher than those in 10 patients with Ⅱdegree heart failure and in the nomal subjects (all P< 0.01 ). As compared with the noed controls , thelevels of serum IL- 8 in the patients with Ⅱ degreeheart failure were significantly elevated (P < 0.01 ).Moreover, there were significantly negativecor relationbetween the levels of serum IL- 8 and PaO2 and pHvalues in the patients during acute phase (r = -0.429 and -0.613, P < 0.02 and < 0.01, respectively). The levels of serum IL- 8, however, werepositively correlated with PaCO2 in the potents (r =0.889, P < 0.01 ). Conclusion The data suggestedthat IL- 8 may night play. an important role in thepathogenesis of the inflammatory process of chronicocr pulmonale, and that measuring serialy the levelsof serum IL- 8 in the patients would be cortributedto monitor the changes of the disease.[更多还原