【摘要】 目的：探讨肾细胞癌与多药耐药的关系。方法：应用免疫组化方法，检测４４例术前未进行化疗的肾细胞癌和１６例正常肾组织中的Ｐ糖蛋白（Ｐ－ｇｐ）和谷胱甘肽－Ｓ－转移酶－π（ＧＳＴ－π）表达。结果：Ｐ－ｇｐ和ＧＳＴ－π在１６例正常肾组织中的表达率均为１００％，在４４例肾细胞癌组织中分别为６３．６％和５４．５％，Ｐ－ｇｐ和／或ＧＳＴ－π阳性表达率为７９．５％。Ｐ－ｇｐ和ＧＳＴ－π的表达与其组织类型有关，与肿瘤的分化程度无关。结论：检测Ｐ－ｇｐ和ＧＳＴ－π对肾细胞癌病人的治疗方案选择和预后判断具有重要的临床意义。更多还原

【Abstract】 Purpose To study the correlation of renal cell carcinoma and multidrug resistance. Methods Fortyfour human renal cell carcinomas of previously untreated patients and 16 normal kidney tissues were studied for the expression of Pglycoprotein(Pgp) and glutathione Stransferaseπ (GSTπ) by means of immunohistochemistry. Results The expressions of Pgp and GSTπ were 100% in the proximal tubules of the kidney, 636% and 545% in renal cell carcinoma tissues, respectively. The expressions of Pgp and/or GSTπ were 795%. There was a correlation between the expression of Pgp/GSTπ and histologic subtypes, but no difference in grades of differentiation in renal cell carcinomas. Conclusions Pgp and GSTπ may have significant clinic value in the evaluation of prognosis and therapy design.更多还原