【摘要】 目的:研究单剂量po布洛芬控释片（A）与缓释胶囊（B）后,血清中的药物动力学与相对生物利用度.方法:采用HPLC法测定18名健康志愿者单剂量po600mgA与B后布洛芬血药浓度的变化,计算药物动力学参数与相对生物利用度,并以配对t检验与双单侧t检验进行统计分析.结果:单剂量po600mgA与B的t_max分别为（3.01±0.90）和（3.45±1.03）h;C_max分别为（16.73±3.28）和（16.05±3.56）mg/L;T_1/2分别为（5.23±0.86）和（5.28±0.72）h;AUC_0→∞分别为（175.89±35.93）和（181.80±41.10）mg·h/L.两种制剂的t_max、C_max和AUC（0→∞）均无显著差异（P>0.05）.结论:两种制剂量给药600mg时为生物等效;以B为标准参比制剂,单剂量给药时A相对生物利用度为（97.37±9.98）%.更多还原

【Abstract】 AIM:To study the pharmacokinetics and relative bioavailability of ibuprofen coutrolled tablets. METHODS: The serum concentration of ibuprofen was determined by HPLC in 18 volunteers after single oral administration 600mg ibuprofen controlled tablets （A） and ibuprofen sustained release capsules （B）. RESULTS: t_max of the tablets and capsules were （3.01±0.90） and （3.45±1.03）h,c_maxwere （16. 73±3. 28）and （16. 05±3. 56）mg/L; T1/2 were （5. 23±0. 86）and （5. 28±0. 72）h;AUC0-∞were （175. 89±35. 93） and （181. 80± 41.10）mg · h/L,respectively. The results of statistical analysis showed that there was no significant difference of t_maxc_maxand AUCo-∞between the two preparations （P>. 05）. CONCLUSION : The bioavailability of ibuprofen controlled tablets reference to ibuprofen sustained release capsules is （97. 37±9. 98）% in single oral administration.更多还原