【摘要】 目的;测定乳酸左氧氟沙星片的相对生物利用度.方法:8名男性健康志愿者交叉po 200mg国产和进口乳酸左氧氟沙星片,采用HPLC法测定血浆中左氧氟沙星的浓度.结果:两种片剂的血药浓度曲线均符合二室模型.其主要药物动力学参数:Ka分别为（0.70±0.26）和（0.68±0.281）h^-1.T_1/2分别为（5.93±3.03）和（4.43±0.66）h,AUC分别为（11.13±2.81）和（11.18±2.89）μg·h/ml.两种片剂药物动力学参数均无明显差异（P>0.05）,国产乳酸左氧氟沙星片的相对生物利用度为100.60%.结论:两种片剂生物等效.更多还原

【Abstract】 AIM: To study the bioavailability of levofloxacin lactate tablets in 8 normal male volunteers. METHODS;A single oral dose of 200mg domestic or imported levofloxacin was given according to a crossover design. The concentrations in plasma were determined by high performance liquid chromatography. RESULTS: The concentration-time curves of domestic and imported products fitted to two-compartment open model. The main pharma-cokinetic parameters were Ka （0. 70±0. 26）and （0. 68±0. 281）h^-1,the T1/2（5. 93±3. 03）and （4. 43±0. 66）h,the AUC （11.13±2.81）and （11.18±2. 89）μg · h/ml,respectively. The pharmacokinetic parameters obtained from our studies showed no significant difference between two products（P>0. 05）.The relative bioavailability of domestic to imported tables-157-was 100. 60%. CONCLUSION:Two preparations are bioequivalent.更多还原