【摘要】 目的:观察顺铂、5-氛尿嘧啶、长春新碱配伍在体外对人肝癌细胞株(7721)的相互作用.方法:采用MTT法利用中效原理判定两药合用的效果.结果:3种药物单独应用时随着药物剂量增加,其效应也增加;两药大剂量(大于中效剂量)合用时可产生拮抗作用(CI>1);小剂量(小于中效剂量)合用时可产生协同作用(CI>1);两药合用时的浓度比例及给药时间次序不同均会影响效应大小.结论:上述3种药物任何两种合用小剂量产生协同作用,大剂量产生拮抗作用,且效应大小与两药浓度比例及给药时间次序有关.更多还原

【Abstract】 AIM:To evaluate the killing effects of CDDP,5-Fu and VCR on human hep-atoma cell line (7721). METHODS: The median-effect principle was used . RESULTS: Killing effects of the individual drugs were enhanced as median concentration increased. We also observed that the interaction of drugs was antagonism at higher concentration (CI>1). Finally,both the ratios of drug concentration and the sequence of adminiatration were factors to influence the killing effects. CONCLUSION:The drug administration order and drug concentrations are significant factors that need to be considered in clinical practice.更多还原