【摘要】 目的:探讨巨块型宫颈癌IB-IIB期术前应用口服氟铁龙及区域性化疗的临床意义.方法:22例宫颈肿瘤大于5cm的stageIB-IIB宫颈癌患者均接受术前口服5’-DFUR 800mg/m~2/天×14天为一疗程第29天再重复.介入化疗,导管超选择至子宫动脉,注入顺铂30mg/m~2/例,表阿霉素25mg/m~ 2/例,第2周为一疗程,共2～3疗程.然后全组病人均行宫颈癌根治术.结果:经术前化疗后宫颈局部肿瘤明显缩小,PR为100%,为彻底手术奠定基础,并使原不能手术者亦成为手术可能.结论:术前化疗对巨块型宫颈癌疗效明显.更多还原

【Abstract】 Purpose: The aim of this study was the objective analysis of the ectent of tumor reduction as well as tue clinical response to tucrapy measured by such parameters as tumor markers and toxicity in primary bulky tumors in clinical stage IB-IIB. Methods: Twcenty-two patients with a bulky primary tumor more than 5cm in diameter were given 5’-DFUR 800mg/m2/day PO, day 1~14, day 29~42 and 30/mg/m2day cisplatin, 25mg/m2 epirubicin intraaterially each side on day 1. The second cycle was given two weeks later. The uterine artery was catheterized bilaterally under arteriographic control. Tumor size was measured with computer tomographic and ultrasonography. In two weeks after the second chemotherapy cycle > a radical hystorectomy and lymphadenectomy were performed. Results: A significant reduction of the original tumor size on averge 84% > range 50% ?95% was observed in this study. Partial response was observed in all patients (response rate 100%). The preoperative tumor reduction allowed a surgical approach in all the patients with a successful radical removed of the tumor. Conclusion: The preoperative chemotherapy is effective for bulky cervical carcinoma.更多还原