【摘要】 56例扩张型心肌病顽固性心衰患者,按其入院顺序被分为两组:用地高辛、利尿剂和血管扩张剂治疗的26例患者为对照组;其余30例除上述药物治疗外,加用美托洛尔为治疗组。经6wk～8wk治疗后,治疗组心率、血压和心功能均有明显改善,治疗组总有效率高于对照组(P<0.01)。结果显示美托洛尔对扩张型心肌病顽固性心衰有一定疗效。 治疗中仅1例在美托洛尔用量为25mg/d时发生三度房室传导阻滞,2例发生症状性窦性心动过缓,未见有心源性休克及心脏性猝死发生。更多还原

【Abstract】 Fifty six cases of dilated cardiomyopathy with refractory heart failure were divided into two groups according to their order of admision. 26 cases were treated with digoxin, diuretics and vasodilators as control group. In another 30 cases, metoprolol was added to above drugs (treatment group). After a course of 6~8 weeks treatment, heart rate, blood pressure and cardiac function in treatment group were improved significantly, The over all effective rate in treatment group was higher than that in control group (P<0. 01). Result indicates that metoprolol has some benifit for dilated cardiomyopathy with refractory heart failure.In treatment group, Ⅲ~。 A - VB had taken place only in 1 case during dose of metoprolol 25 mg/d. Symptomatic sinus bradycardia had taken place in 2 cases. No cardiogenic shock or sudden cardiac death had been found.更多还原