【摘要】 目的:研究血清Ⅳ型胶原在慢性肝病上的诊断价值并与血清层粘蛋白、透明质酸比较.方法:用放免法(RIA)测定114例各种肝病患者及30例正常对照者的血清Ⅳ型胶原、层粘蛋白和透明质酸的水平.结果:与正常对照比较慢性肝炎、肝硬化和肝细胞癌患者血清Ⅳ型胶原含量升高极显著(P<0.01),层粘蛋白和透明质酸含量亦显著升高(P<0.05).与慢性肝炎、肝硬化比较肝细胞癌患者血清中Ⅳ型胶原含量升高明显(P<0.05);结沦:血清Ⅳ型胶原为判断肝纤推化的良好指标.更多还原

【Abstract】 Objective: To study clinical evaluation of serum type Ⅳ collogen in chronic liver diseases in comparison with serum laminin, hyaluronic acid. Methods: Serum type Ⅳ collogen, laminin, hyaluronic acid were determined by means of RIA in 114 patients with various liver diseases and 30 healthy control. Results: Serum type Ⅳ collogen levels was significantly increased in chronic hepatitis, liver cirrhosis and primary hepatic carcinoma (P< 0.001). Serum laminin and hyaluronic acid levels were increased also ( P < 0.05). While type Ⅳ collagen levels in primary hepatic carcinoma was higher than are of chronic hepatitis and liver cirrhosis (P<0.05). Conclusion; Serum type Ⅳ collagen is a valuable clinical marker for determining hepaticfibrosis.更多还原