【摘要】 目的：研究冠心病的抗凝血酶Ⅲ（AT-Ⅲ）及纤溶改变特点并探讨其临床意义。方法：对冠心病组（34例）及对照组（30例）的抗凝血酶Ⅲ抗原（AT-Ⅲ：Ag）、抗凝血酶Ⅲ活性（AT-Ⅲ：a）、纤溶酶原抗原（PLG：Ag）、纤溶酶活性（PL：a）、组织型纤溶酶原激活剂活性（t－PA：a）、纤溶酶原激活剂抑制剂活性（PAI：a）和D-二聚体（D-dimer）进行检测和分析。结果：冠心病组的AT-Ⅲ：a显著降低（P＜0．01），PAI；a显著增高（P＜0．01），PL：a及D-dimer显著增高（P＜0．05，0．01）。t－PA：a与PL：a，t－PA：a、PL：a与D-dimer呈正相关。冠心病组中，不稳定型心绞痛及冠状动脉多支病变者与稳定型心绞痛及单支病变者比较，PL：a、t－PA：a、PAI：a及D-dimer增高尤显（均P＜0．05）。结论：冠心病特别是不稳定型心绞痛及冠状动脉多支病变者存在高凝状态和纤溶活性增高。更多还原

【Abstract】 Objectives:To study the clinical siedficance of changes of antithrombin Ⅲ and fibrinolysis in coronary heart disease. Methods:: Antithrombin Ⅲ antigen (AT-Ⅲ： Ag), antithrombin Ⅲ activity (AT-Ⅲ:a),plasminogen antigen (PLG: Ag),plasmin activity (PL:a),tissue plasminogen activator activity (t-PA:a),plasminogn activator inhibitor activity(PAI:a) and ixdimer were studied in 34 cases of coronary heart disease (CHD) and30 normal controls. Results:AT-Ⅲ:a was significantly lowered (P <0.01) ； PAI: a, PL: a and D-dimer were significantly increased (P < 0.01, 0.05 & 0.01 respectively)in CHD. There were postive correlations between t-PA: a and Ddimer (r = 0.529, P r0.01),t-PA:a and D-dimer(r = 0. 795, P <0.01),and PL:a and D-dimer (r=0.587, P<0.01). In patients with stable angina (SA) and unstable angina (UA) PL: a, t-PA: a, and D-dimer were significantly increased in later (P <0.05). Patients with multivessel disease showed much decreased AT-Ⅲ:a and increased PL:a,t-PA:a and D-dimer than single ves-sel disease (P＜0.05). Conclustiou： There are increase of coagulability and fibrinolysis in CHD especially in UA and multivessel disease.更多还原