【摘要】 为了探讨活血化瘀中药治疗系统性硬皮病（SS）的药理机制，以体外培养的SS病人的皮肤成纤维细胞为研究对象,采用MTT方法对21种常用活血化瘀中药的水溶性提取物对该细胞增殖的影响进行了研究.结果显示，17种药物对该细胞增殖具有抑制作用，其中以赤芍、丹参、红花、丹皮、茜草、乳香、没药、苏木、牛膝和泽兰的抑制作用显著，且分别呈剂量效应关系和时间效应关系本研究结果可为今后SS治疗时中药组方选择药物提供依据。更多还原

【Abstract】 In order to investigate the pharmacologic mechanism of 21 traditional chinese medicine of promoting blood circulation to remove blood stasis in the treatment of sys temic scleroderma (SS).we used the cultured SS skin fibroblasts as an experimental model and detected the effects of the water soluble extracts of the drugs on the cell proliferation by MTT assay. The results showed that 17 drugs among them could inhibit the proliferation of the cells and the drugs such as Paeonia lactiflora. Salvia miltiorrhiza. Carthamus tinctorius.Paeonia suffruticosa. Rubia cordifolia. Olibanum. Myrrh. Cae salpinia sappan.Achyranthes bidentata and Lycopus lucidus could significaltly inhibit the proliferation. The effects were increased while the concentration of the drugs were raised or the given period of time were prolonged. The results above may be used as a basis while prescribing a traditional chinese medicine recipe in the treatment of SS.更多还原