【摘要】 目的和方法：４０例心胸手术应用异丙酚麻醉。其诱导剂量为１～１．５ｍｇ／ｋｇ，维持量为１．７２～４．９６ｍｇ·ｋｇ－１·ｈ－１。结果：诱导期低血压１例，心动过缓１例。维持期心动过缓１例。１０例在诱导时采用无创心功能测定，资料显示诱导后ＣＩ、ＳＩ和ＥＶＩ分别下降９．６％±５．５％、１２．０％±８．０％和７．８％±５．８％（Ｐ均＜０．０５）。２０例在诱导时血液动力学监测显示，诱导后ＳＢＰ、ＤＢＰ和ＭＡＰ分别下降１５．２％±２．４％、１４．９％±３．８％和１５．１％±２．８％（Ｐ均＜０．０５）。结论：异丙酚具有起效快、苏醒快、麻醉深度易于调节等优点。但该药对循环功能仍有相当程度影响。因此，在老年、高血压、心功能差的病人，诱导时减量为妥。另外合并使用潘库溴铵可有效预防心动过缓的发生。更多还原

【Abstract】 undergoing cardiothoracic surgery. The induction dose of propofol was 1～15mg/kg and anesthesia was maintained by continuously infusing in a dose of 172～496mg·kg-1·h-1. Results: Hypotension was seen in one case and bradycardia in another one during induction. Cardiac function was monitored noninvasively during induction in 10 patients. It was found that, after induction, CI, SI and EVI decreased by 96±55%,120±80% and 78±58% respectively while SBP, DBP and MAP were decreased by 152±24%,149±38%　and 151±28% respectively. Conclusions: The results indicate that propofol has the advantages of quick onset, short action and easy regulation of anesthetic depth. Propofol, however, still has a circulatory depression. Care, therefore, should be taken when used in the elderly or the patients with hypertension or poor cardiac function and it should be given in a reduced dose. Pancuronium has a preventive effect on the bradycardia produced by propofol.更多还原