【摘要】 目的与方法：用清醒动物研究了吗啡与氯胺酮的相互作用。结果与结论：吗啡可增大氯胺酮引起的小鼠入睡率、延长小鼠睡眠时间、增强氯胺酮的镇痛作用，并能拮抗氯胺酮的升压效应。但吗啡可加重氯胺酮对兔的呼吸抑制，大剂量（１００ｍｇ／ｋｇ，ｉｖ）可减小小鼠静注氯胺酮的ＬＤ５０。更多还原

【Abstract】 bjecttive and Methods: The interaction between morphine(M) and ketamine(K) was studied in conscious animals. Results and Conclusion: M increased the incidence of sleep caused by K and prolonged the sleep duration and potentiated analgesic action of K in mice. M (6mg·kg-1,iv) could also inhibit the Kinduced hypertensive effect in rabbits. But M potentiated respiratory inhibition induced by K in rabbits. Large dose of M (100mg·kg-1,ip) decreased the LD50 of K in mice.更多还原