【摘要】 本文采用免疫组化、PCR技术，检测30例涎腺肿瘤组织中c－myc、P53、Bcl－2蛋白表达和HPV感染。结果显示：多形性腺瘤中，c－myc和P53阳性率分别为50．0％和25．0％，均低于恶性肿瘤阳性率的75．0％和50．8％，两组存在高度显著性差异（P＜0．01）；15例多形性腺瘤和3例鳞癌中，HPV6．11均为阴性，HPV16．18阳性反应各1例（1／15和1／3）。提示c－myc表达升高，与上皮细胞增殖速度加快及细胞癌变有关；P53蛋白表达，可为判断细胞分化程度的参考指标；HPV16．18具一定协同致癌作用。Bcl－2能引起细胞过度积聚，故为恶性肿瘤的发病机制之一。更多还原

【Abstract】 c-myc,P53 proteins and infections of HPV in salivary gland tumous were detected by immunohistochemical method and PCR. The results showed that in PA, the positive rates of c-myc and P53 were 50. 0% and 25. 0%. Both of them were lower than those of malignant tumours (75. 0% and 50. 8%). there were high defferances between two groups (P<0. 01 ). In 15 cases of PA and 3 cases of SCC, HPV6. 11 rections were all negative, but in 1 case of PA and 1 case of SCC, HPV16.18 staining were positive. The study indicates c-myc expressions were associated with cell proliferation and mutation, P53 overexpression can be a reference for cell differentiation. HPV16. 18 play a cooperation role in carcinogen. Because Bc1- 2 Could bring about cell accumulation, so it is one of mechanism for malignent tumour.更多还原