【摘要】 为探讨人乳头状瘤病毒（HPV）感染与鼻内翻性乳头状瘤（IP）发病及其恶变的关系，研究选取经组织病理确诊为IP（36例）和IP癌变（16例）的石蜡包埋标本，采用多聚酶链反应（PCR）方法对标本进行HPV相关DNA序列扩增。结果显示；36例IP组织有21例（58．3％）为HPV阳性；16例IP癌变组织中有11例（68．8％）阳性。经统计学处理，二者间无显著性差异（P＞0．05）。提示HPV感染在IP的发生过程中发挥一定的作用，而IP癌变的过程还需要HPV感染以外的致癌因素参与。更多还原

【Abstract】 In order to elucidate the relationship of human papilloma virus (HPV) infection and pathogenesis of nasal inverted papilloma (IP) and its malignant transformation,36 cases of IP and 16 cases IP with squamous cell carcinoma (IP+SCC) were detected for HPV related sequence with Polymerase Chain Reaction (PCR) method. HPV related sequence were found in 21 of 36 (58. 3%)cases of IP and in 11 of 16 (68. 8% ) cases of IP+SCC. The difference of positive rates of HPV in IP and IP+SCC were not significant statistically. The results suggested that HPV infection may play an important role in the pathogenesis of IP,and other factor (s) may be needed in the IP malignant transformation in addition to HPV infection.更多还原